Quite a few recent studies have suggested that obesity is associated with chronic inflammation in fat tissue. Over the last few months researchers at the Sanford-Burnham Medical Research Institute have found out that an imbalance between an enzyme and its inhibitor are causing a umber of factors including inflammation, insulin resistance, obesity and fatty liver disease.
The researchers discovered that obese humans have an increased level of activity in an enzyme called neutrophil elastase which was further complicated by decreased level in a protein that inhibits the activity of the elastase.
Taking this forward the team used mice in order to find out what would happen when they reverse this imbalance and at the same time fed the mice a high fat diet. It turned out that the mice became resistant to body weight gain, their insulin resistance was reversed and the occurrence of fatty liver disease was significantly reduced.
You can find out more about this and the work of Zhen Jiang, Ph.D. by following the link below.